Obstetrician/gynecologist Mindy Lahiri tries to balance her personal and professional life, surrounded by quirky co-workers in a small medical practice in New York City.
Rob (guest star Tate Ellington) gives Mindy an opportunity to start up her own practice in San Francisco, and she struggles to tell Danny, especially when Danny shows her the brownstone he bought for the two of them in New York! Meanwhile, Jeremy and Peter grapple with the fact that Lauren is moving to Texas and leaving them both behind.
Mindy has some big news to tell Danny but, just as she is getting ready to tell him, his father (guest star Dan Hedaya) and half-sister (guest star Madison Moellers) show up for an unexpected visit. The whole crew is invited to Annette's house for the world's most awkward family dinner.
Mindy has made up her mind to move to San Francisco and start a practice with Rob, but her credit history jeopardizes their ability to get a loan. Meanwhile, Danny tries to let the office know that he is moving to San Francisco with Mindy, but they're convinced his "big news" is something completely different.
Mindy struggles with her body image as her baby bump begins to show, so she agrees to meet with Sheena, an aspiring personal stylist. Meanwhile, Jeremy, heartbroken over Lauren, tries to dive back into the dating pool, and unexpectedly runs into Morgan's girlfriend, Jessica.
Mindy starts to question Danny's commitment to their relationship when he's a no-show for dinner with her parents. Meanwhile, when Morgan thinks he overhears Mindy saying Danny is not the father of her baby, he gathers all the guys with whom she's ever slept, in an attempt to figure out who is the real father.
As Mindy adjusts to her long-distance relationship with Casey, she also must adjust to the fact that she is no longer the office's "Dr. L" - her office, patients and dignity have been overtaken by Dr. Paul Leotard - so she challenges Paul to get her former life back. Meanwhile, Danny has a new extracurricular activity following his breakup with Christina.
After returning from Haiti, Casey has an identity crisis and thinks being a disc jockey might be his new calling. When Mindy and the office go to a music festival for their “work retreat” to see Casey perform, the substance-filled surroundings lead to a series of disasters. Meanwhile, back in New York, Jeremy hires a new doctor, whom Mindy doesn’t particularly like after he saves the day during an emergency delivery.
According to Morgan, anyone who sleeps with him will find the love of their life immediately afterward. Curious to test this theory, Mindy takes Morgan up on his offer, but backs out at the last minute, humiliating Morgan and prompting him to sue Mindy for sexual harassment. In order to get out of the lawsuit and get back into Morgan's good graces, Mindy makes him an offer he can't refuse.
When Mindy tells Danny she has a crush, he thinks she's talking about him instead of Cliff the lawyer. Meanwhile, Morgan and Peter find Mindy's phone and respond to a text from Cliff, which starts off innocently, but escalates into something that may lead to unintended romantic consequences.
When Shauna takes the office to the hottest nightclub in town, Mindy meets an unlikely potential suitor named Josh, who works as a lawyer for the New York Knicks. Meanwhile, Jeremy attempts to hit on a bride-to-be, and Morgan unexpectedly makes some extra cash as the club's bathroom attendant.
When Mindy must find a new gynecologist, she asks Danny to assume the role. Eventually, he accepts - on the grounds that Mindy will feel too uncomfortable to go through with the exam. The two then play a game of chicken to see who will back out of the deal first. Meanwhile, Jeremy tricks Morgan and Betsy into helping him break into Mindy's apartment to retrieve a valuable item.
When Mindy throws an office Christmas party at her apartment, she is eager for her colleagues to finally meet her boyfriend, Josh, but her plans go awry when she discovers a secret that Josh has been hiding. Meanwhile, Jeremy deals with doling out the office holiday bonuses, much to everyone's chagrin.
Mindy's goddaughter, Riley, demands that Mindy get a bunk bed for their sleepover. But Mindy's plan veers off-track when Morgan and Danny help to build the bed, and it collapses, injuring Gwen in the process. Meanwhile, Shauna and Betsy find some surprising items when they snoop through the office in an attempt to find out who's stealing the People magazines.
Mindy tries to solve Jaime's best friend problem by pairing up Lucy with Danny on a Valentine's Day double date. However, Danny and Lucy hit it off immediately and sparks fly, ruining Mindy and Jaime's date. Meanwhile, on his way to his hot Valentine's hook-up, Jeremy helps Morgan with his pickup skills.
Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.
Danny gets caught sneaking out the office supply of painkillers for his troublemaker childhood friend Stevie who has instant chemistry with Mindy. Meanwhile, Mindy is in for a shock when Heather, Josh's ex-girlfriend who ruined Mindy's Christmas party, shows up at her doorstep to ask for her blessing to move into her apartment building. Mindy says yes, but immediately begins to plot ways to ruin Heather's rental application.
When Mindy goes on a date with a cute minister named Casey, she feels compelled to attend his church to show him that she is a good person. But when Casey admits to Mindy that he thinks she's a selfish person, she decides to go on the practice's volunteer trip to a women's prison to prove him wrong.
As the doctors of Schulman and Associates prepare for a medical conference in Santa Fe, NM, Mindy receives a message from her ex-boyfriend, Josh, who is now living there and wants to talk. But Mindy is in for a surprise when she discovers why Josh moved west. Meanwhile, Morgan helps Jeremy work on a potentially career-changing presentation, which doesn’t go according to plan.
When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.
Mindy acts as a mentor to a college student. But when Casey and Mindy unexpectedly hit a rough patch, she decides to drown her sorrows at a frat party where she reunites with her old flame, Tom, and all hell breaks loose. Meanwhile, Danny and Jeremy try to woo Morgan away from the midwives.
Mindy makes the bold decision to move to Haiti with Casey for a year, much to the amusement of her co-workers. In order to prove that she can survive in rough conditions, Mindy invites herself and Casey on a camping trip with Danny and his ex-wife, Christina, with whom he has recently reconciled.